Greek Registry for Amyotrophic Lateral Sclerosis (ALS-GR): An Observational Cohort of Individuals With ALS Across 11 Specialized Centers in Greece.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Liampas Ioannis, Kimiskidis Vasilios K, Zouvelou Vasiliki, Veltsista Dimitra, Moscholouri Afroditi, Triantafyllou Eleftherios, Daponte Ariadni, Xirou Sofia, Sterpi Angeliki-Erato, Salakou Stavroula, Poulidou Vasiliki, Arnaoutoglou Marianthi, Tsouris Zisis, Ralli Styliani, Dardiotis Efthimios, Papagiannopoulos Sotirios, Zampetakis Alexandros, Zaganas Ιoannis, Mitsias Panayiotis, Giannakis Alexandros, Konitsiotis Spyridon, Kefalas Fotios, Alexiou Eleni, Stoiloudis Panagiotis, Parissis Dimitrios, Kiamelidis Stratis, Terzoudi Aikaterini, Tsivgoulis Georgios, Rentzos Michail, Chroni Elisabeth
Аннотация
METHODS: We performed an observational cohort study in 11 specialized centres across Greece. Adult individuals with ALS diagnosed based on the Gold Coast criteria were recruited. Data were collected on socio-demographics, somatometrics, comorbidities, early life exposures, disease-related parameters, riluzole intake, motor and non-motor symptoms, as well as functional progression. Follow-up evaluations were scheduled on approximately 6-9-12-18-24 months. Our aim was to identify shortcomings in the monitoring of patients with ALS in specialized centers, delineate the course of the disease, and capture factors related to the earlier occurrence of ALS and potential diagnostic delays.
RESULTS: A total of 229 ALS patients were included in the present registry. The average age of diagnosis was 63.7 years, with an average 12.8-month interval between symptom onset and diagnosis. The presence of bulbar symptoms at onset was associated with shorter diagnostic delays. Systematic physical exercise was strongly linked to the earlier onset of symptoms. Disease progression was slower during the prediagnostic stage, more precipitous over the first year following diagnosis, and milder thereafter (~1-point monthly decline in ALSFRS-R on average, post-diagnosis). The majority of associated motor and non-motor symptoms accumulated over time. The overwhelming majority of patients were prescribed the liquid form of riluzole, which exhibited an excellent tolerability profile. Greek islands are probably the most underprivileged in terms of specialized monitoring of ALS cases.
CONCLUSIONS: The present observational cohort study mapped key aspects and shortcomings of ALS management in Greece.