Photodiagnosis and photodynamic therapy · 2025
Impact of photodynamic therapy combined with Anti-VEGF vs. Anti-VEGF monotherapy on choriocapillaris vessel density in polypoidal choroidal vasculopathy.
СтатьяНаблюдательное исследованиеСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Kuo Po-Chin, Hsu Sheng-Min, Huang Yi-Hsun, Chang Chun-Hsiang, Chang Yi-Sheng, Hung Jia-Horung, Lai Chun-Chieh, Lee Yu-Kuei
Аннотация
PURPOSE: To compare the choriocapillaris vessel density between intravitreal ranibizumab (Lucentis) (IVR) plus photodynamic therapy (PDT) and intravitreal aflibercept (Eylea) (IVA) monotherapy in patients experiencing polypoidal choroidal vasculopathy (PCV).
DESIGN: An observational, retrospective cohort study.
SUBJECTS: Adults with treatment-naïve PCV.
INTERVENTION: IVR plus PDT or IVA monotherapy.
MAIN OUTCOME MEASURES: After propensity-score (PS) matching, study outcomes were compared at 1 month after the final treatment. The primary outcome was a choriocapillaris vessel density, recognized by optical coherence tomography angiography (OCTA). The secondary outcomes included best corrected visual acuity (BCVA), presence of retinal hemorrhage, central macular thickness (CMT) and subfoveal choroidal thickness (SFCT), assessed by optical coherence tomography (OCT).
RESULTS: Initially, 23 patients receiving IVR plus PDT, and 75 patients receiving IVA monotherapy were included. After PS-matching, 19 eyes of 19 patients receiving IVR plus PDT and 38 eyes of 38 patients receiving IVA monotherapy were analyzed. A significantly lower choriocapillaris vessel density in the IVR plus PDT group than the IVA monotherapy group (41.9 % vs. 52.2 %, p = 0.009) was demonstrated. The similarity of the BCVA, occurrence and severity of retinal hemorrhage, CMT, and SFCT between two treatment groups was exhibited.
CONCLUSIONS: The choriocapillaris vessel density was significantly reduced in PCV patients treated with IVR plus PDT compared to those receiving IVA monotherapy.
DESIGN: An observational, retrospective cohort study.
SUBJECTS: Adults with treatment-naïve PCV.
INTERVENTION: IVR plus PDT or IVA monotherapy.
MAIN OUTCOME MEASURES: After propensity-score (PS) matching, study outcomes were compared at 1 month after the final treatment. The primary outcome was a choriocapillaris vessel density, recognized by optical coherence tomography angiography (OCTA). The secondary outcomes included best corrected visual acuity (BCVA), presence of retinal hemorrhage, central macular thickness (CMT) and subfoveal choroidal thickness (SFCT), assessed by optical coherence tomography (OCT).
RESULTS: Initially, 23 patients receiving IVR plus PDT, and 75 patients receiving IVA monotherapy were included. After PS-matching, 19 eyes of 19 patients receiving IVR plus PDT and 38 eyes of 38 patients receiving IVA monotherapy were analyzed. A significantly lower choriocapillaris vessel density in the IVR plus PDT group than the IVA monotherapy group (41.9 % vs. 52.2 %, p = 0.009) was demonstrated. The similarity of the BCVA, occurrence and severity of retinal hemorrhage, CMT, and SFCT between two treatment groups was exhibited.
CONCLUSIONS: The choriocapillaris vessel density was significantly reduced in PCV patients treated with IVR plus PDT compared to those receiving IVA monotherapy.
Предметные рубрики MeSH
HumansPhotochemotherapyMaleRanibizumabFemaleRetrospective StudiesAgedReceptors, Vascular Endothelial Growth FactorMiddle AgedAngiogenesis InhibitorsTomography, Optical CoherenceChoroidRecombinant Fusion ProteinsIntravitreal InjectionsVascular Endothelial Growth Factor APhotosensitizing AgentsVisual AcuityFluorescein AngiographyChoroidal NeovascularizationPolypoidal Choroidal Vasculopathy