Shanghai kou qiang yi xue = Shanghai journal of stomatology · 2016
[Correlation of Treg and IL-15 expression in the peripheral blood of patients with oral lichen planus].
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Wang Cui-Jie, Li Yan-Jun, Xue Jiang-Nan, Ci Hao-Su, Li Li-Ping, Li Ling
Аннотация
PURPOSE: To investigate the expression of Treg and IL-15 in the peripheral blood of patients with oral lichen planus (OLP).
METHODS: The peripheral blood was obtained from 36 OLP patients and 20 healthy controls. Flow cytometry was used to evaluate the proportion of Treg cells, and the level of IL-15 was measured by ELISA. The data were analyzed by SPSS 16.0 software package.
RESULTS: In the peripheral blood of OLP patients, the proportion of CD4+CD25+Foxp3+ Treg cells and IL-15 content were significantly higher than those of the healthy controls (P<0.05), but there were no significantly difference between two clinical subtypes of OLP(P>0.05). The proportion of CD4+CD25+Foxp3+Treg cells was positively correlated with the level of IL-15(r=0.70,P<0.05).
CONCLUSIONS: The high expression of Treg cells and IL-15 in the perpheral blood of OLP patients may be responsible for the pathogenesis of OLP.
METHODS: The peripheral blood was obtained from 36 OLP patients and 20 healthy controls. Flow cytometry was used to evaluate the proportion of Treg cells, and the level of IL-15 was measured by ELISA. The data were analyzed by SPSS 16.0 software package.
RESULTS: In the peripheral blood of OLP patients, the proportion of CD4+CD25+Foxp3+ Treg cells and IL-15 content were significantly higher than those of the healthy controls (P<0.05), but there were no significantly difference between two clinical subtypes of OLP(P>0.05). The proportion of CD4+CD25+Foxp3+Treg cells was positively correlated with the level of IL-15(r=0.70,P<0.05).
CONCLUSIONS: The high expression of Treg cells and IL-15 in the perpheral blood of OLP patients may be responsible for the pathogenesis of OLP.