Frontiers in endocrinology · 2026
A case report and literature review of proton pump inhibitors inducing insulin autoimmune syndrome.
СтатьяКлинический случайОбзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhang Wenrui, Wen Jiayan, Qi Siming, Zhang Guohui, Yang Xubin, Zeng Longyi, Xu Wen, Deng Hongrong
Аннотация
BACKGROUND: Insulin autoimmune syndrome (IAS) is an autoimmune endocrine disorder characterized by hyperinsulinemia, positive insulin autoantibodies (IAA), and hypoglycemia. IAS was previously thought to be induced by drugs containing thiol groups.
OBJECTIVE: We describe a case highlighting that IAS may be temporally associated with a proton pump inhibitor (PPI) exposure. This article reports a patient who took beraprost sodium, clopidogrel, atorvastatin calcium, and the PPI pantoprazole and was subsequently diagnosed with IAS, presenting with a high IAA level, refractory hypoglycemia, and markedly elevated insulin levels. The patient's hypoglycemic episodes were ultimately relieved after discontinuation of the PPI, accompanied by a gradual decrease in the IAA level to the normal range.
KEY FINDINGS: HLA analysis revealed HLA-DRB1*0403, DQB1*0302, and DQA1*0301, indicating the patient's genetic susceptibility to IAS, which was possibly triggered by the PPI.
CLINICAL RELEVANCE: This case report may alert clinicians to possible PPI-associated IAS, helping to avoid misdiagnosis and enable patients to receive timely treatment.
OBJECTIVE: We describe a case highlighting that IAS may be temporally associated with a proton pump inhibitor (PPI) exposure. This article reports a patient who took beraprost sodium, clopidogrel, atorvastatin calcium, and the PPI pantoprazole and was subsequently diagnosed with IAS, presenting with a high IAA level, refractory hypoglycemia, and markedly elevated insulin levels. The patient's hypoglycemic episodes were ultimately relieved after discontinuation of the PPI, accompanied by a gradual decrease in the IAA level to the normal range.
KEY FINDINGS: HLA analysis revealed HLA-DRB1*0403, DQB1*0302, and DQA1*0301, indicating the patient's genetic susceptibility to IAS, which was possibly triggered by the PPI.
CLINICAL RELEVANCE: This case report may alert clinicians to possible PPI-associated IAS, helping to avoid misdiagnosis and enable patients to receive timely treatment.