Journal of clinical and diagnostic research : JCDR · 2016
Expression of CD1a by Langerhan's Cells in Oral Lichen Planus - A Retrospective Analysis.
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Kulkarni Ganesh, Sakki Esther Priyadarshini, Kumar Yennavaram Vijay, Kolimi Sadananda, Perika Ravi, Karthik Kalepu Venkata, Kumar Kandukuri Mahesh, Kalyan Venumbaka Siva
Аннотация
INTRODUCTION: Langerhan's Cells (LCs) are dendritic cells of the oral epithelium which play a role in a series of oral lesions from gingivitis to oral cancer. Oral Lichen Planus (OLP) is an oral mucosal T-lymphocyte mediated immunologic reaction to an unidentified putative antigen or allergen.
AIM: The aim of this study was to quantify the presence of immature LCs in OLP comparing them with normal epithelium.
MATERIALS AND METHODS: A retrospective study using 30 of OLP cases were conducted. Immunohistochemistry was performed using polyclonal anti-CD1a antibodies to identify LCs in 10 cases of normal tissue and 30 samples of OLP. The distribution of LCs among lesional tissue and normal mucosa was analysed using Mann-Whitney U test.
RESULTS: LC population in OLP was significantly higher when compared to the normal epithelium (p<0.001).
CONCLUSION: The increase in LCs indicates the active role played during the antigen detection in OLP and subsequent presentation to T-lymphocytes.
AIM: The aim of this study was to quantify the presence of immature LCs in OLP comparing them with normal epithelium.
MATERIALS AND METHODS: A retrospective study using 30 of OLP cases were conducted. Immunohistochemistry was performed using polyclonal anti-CD1a antibodies to identify LCs in 10 cases of normal tissue and 30 samples of OLP. The distribution of LCs among lesional tissue and normal mucosa was analysed using Mann-Whitney U test.
RESULTS: LC population in OLP was significantly higher when compared to the normal epithelium (p<0.001).
CONCLUSION: The increase in LCs indicates the active role played during the antigen detection in OLP and subsequent presentation to T-lymphocytes.