Obstetrics and gynecology · 2012
Pregnancy in a woman with congenital generalized lipodystrophy: leptin's vital role in reproduction.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Maguire Marcy, Lungu Andrea, Gorden Phillip, Cochran Elaine, Stratton Pamela
Аннотация
BACKGROUND: Congenital generalized lipodystrophy is a rare disorder characterized by scant adipose tissue, profound leptin deficiency, and severe insulin resistance, resulting in multiple metabolic derangements, including hyperandrogenism, anovulation, and impaired fecundity.
CASE: A young woman with congenital generalized lipodystrophy receiving leptin therapy experienced menarche, conceived spontaneously, and delivered a liveborn male neonate.
CONCLUSION: Adipose tissue is important to normal female reproductive function. Leptin in particular appears to play a key role in adipose-mediated regulation of fertility.
CASE: A young woman with congenital generalized lipodystrophy receiving leptin therapy experienced menarche, conceived spontaneously, and delivered a liveborn male neonate.
CONCLUSION: Adipose tissue is important to normal female reproductive function. Leptin in particular appears to play a key role in adipose-mediated regulation of fertility.