Emerging infectious diseases · 2017
Human Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China.
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Ke Changwen, Mok Chris Ka Pun, Zhu Wenfei, Zhou Haibo, He Jianfeng, Guan Wenda, Wu Jie, Song Wenjun, Wang Dayan, Liu Jiexiong, Lin Qinhan, Chu Daniel Ka Wing, Yang Lei, Zhong Nanshan, Yang Zifeng, Shu Yuelong, Peiris Joseph Sriyal Malik
Аннотация
The recent increase in zoonotic avian influenza A(H7N9) disease in China is a cause of public health concern. Most of the A(H7N9) viruses previously reported have been of low pathogenicity. We report the fatal case of a patient in China who was infected with an A(H7N9) virus having a polybasic amino acid sequence at its hemagglutinin cleavage site (PEVPKRKRTAR/GL), a sequence suggestive of high pathogenicity in birds. Its neuraminidase also had R292K, an amino acid change known to be associated with neuraminidase inhibitor resistance. Both of these molecular features might have contributed to the patient's adverse clinical outcome. The patient had a history of exposure to sick and dying poultry, and his close contacts had no evidence of A(H7N9) disease, suggesting human-to-human transmission did not occur. Enhanced surveillance is needed to determine whether this highly pathogenic avian influenza A(H7N9) virus will continue to spread.