Future science OA · 2023
Identification of shared fatty acid metabolism related signatures in dilated cardiomyopathy and myocardial infarction.
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Huang Baoyi, Lin Hanying, Zhang Qingfang, Luo Yujun, Zhou Biyao, Zhuo Zewei, Sha Weihong, Wei Jiahui, Luo Lihua, Zhang Huajuan, Chen Kequan
Аннотация
AIM: It is to be elucidated the risk-predictive role of differentially expressed fatty acid metabolism related genes (DE-FRGs) in dilated cardiomyopathy (DCM) and myocardial infarction.
MATERIALS & METHODS: Four gene enrichment analyses defined DE-FRGs' biological functions and pathways. Three strategies were applied to identify risk biomarkers and construct a nomogram. The 4-DE-FRG correlation with immune cell infiltration, drugs, and ceRNA was explored.
RESULTS: DE-FRGs were enriched in lipid metabolism. A risk nomogram was established by ACSL1, ALDH2, CYP27A1 and PPARA, demonstrating a good ability for DCM and myocardial infarction prediction. PPARA was positively correlated with adaptive immunocytes. Thirty-five drugs are candidate therapeutic targets.
CONCLUSION: A nomogram and new biological targets for early diagnosis and treatment of DCM and myocardial infarction were provided.
MATERIALS & METHODS: Four gene enrichment analyses defined DE-FRGs' biological functions and pathways. Three strategies were applied to identify risk biomarkers and construct a nomogram. The 4-DE-FRG correlation with immune cell infiltration, drugs, and ceRNA was explored.
RESULTS: DE-FRGs were enriched in lipid metabolism. A risk nomogram was established by ACSL1, ALDH2, CYP27A1 and PPARA, demonstrating a good ability for DCM and myocardial infarction prediction. PPARA was positively correlated with adaptive immunocytes. Thirty-five drugs are candidate therapeutic targets.
CONCLUSION: A nomogram and new biological targets for early diagnosis and treatment of DCM and myocardial infarction were provided.