Abnormal Resting-State EEG delta and alpha rhythms in Huntington's and Alzheimer's Diseases: An exploratory study.
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Jakhar Dharmendra, Noce Giuseppe, Del Percio Claudio, Lopez Susanna, Carducci Filippo, Lizio Roberta, De Bartolo Mina, Henao Isaza Verónica, Macrì Asia, Soricelli Andrea, Salvatore Marco, Ciccarelli Giuseppina, Galluccio Simona, Di Cecca Angelica, Aiello Marco, Güntekin Bahar, Yener Görsev, Massa Federico, Arnaldi Dario, Famà Francesco, Pardini Matteo, Ferri Raffaele, Lanuzza Bartolo, Stocchi Fabrizio, Vacca Laura, Coletti Chiara, Marizzoni Moira, Taylor John-Paul, Hanoğlu Lutfu, Yırıkoğulları Harun, Kıyı Atilla İlayda, Kula Hilal, Frisoni Giovanni B, Cuoco Sofia, Barone Paolo, Bonanni Laura, D'Anselmo Anita, Biundo Roberta, Cauzzo Simone, Fiorenzato Eleonora, Antonini Angelo, D'Antonio Fabrizia, Bruno Giuseppe, Fabbrini Giovanni, Conte Antonella, Leodori Giorgio, Giubilei Franco, Infarinato Francesco, Marziali Simone, De Pandis Maria Francesca, Delussi Marianna, Salvatore Elena, De Tommaso Marina, Babiloni Claudio
Аннотация
METHODS: Clinical and rsEEG data were collected from 35 patients with HD, 81 patients with AD, and 102 healthy controls (HC). The rsEEG cortical source activations from 30 electrodes were estimated using eLORETA and were harmonized across clinical sites.
RESULTS: Compared to the HC group, both the HD and AD groups showed widespread increases in rsEEG delta source activation and decreases in alpha source activation, with the HD patients exhibiting the most pronounced frontal effects. In patients with HD, those abnormal rsEEG source activations were associated with cognitive, motor, and functional deficits.
CONCLUSIONS: Patients with HD were characterized by a particular slowing of frontal rsEEG rhythms associated with clinically relevant variables.
SIGNIFICANCE: A topographically widespread slowing of cortical oscillatory activity was observed in both HD and AD groups, with a particularly pronounced frontal effect in HD, which may predict a greater impact on the sleep-wake cycle. These observations should be considered exploratory and need validation in future studies with enhanced vigilance monitoring during longer rsEEG recordings.