[Effects of dexamethasone on mucin gene expression in human nasal polyps].

OBJECTIVE

To clarify whether glucocorticoid influences mucin 8 gene expression in human nasal polyps.

METHOD: Thirty patients were randomly divided into two groups. The first group were given dexamethasone intravenously before surgery. We make sure the second group of patients didn't receive any kind of glucocorticoid therapy during thirty days before surgery. MUC8 MRNA expression in nasal polyps of each group was detected by reverse transcription polymerase chain reaction (RT-PCR).

RESULT: The MUC8 MRNA expression in the first group (0.71 +/- 0.34) was lower than that of the second group (1.12 +/- -0.26).

CONCLUSION

DXM supress MUC8 MRNA expression in nasal polyps and this result provide another aspect for glucocorticoid's antiinflammatory mechanism.