Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology · 2004
[Eosinophil apoptosis in nasal polyposis tissue after bleomycin A5 local injection].
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Zhang Xianghong, Zou Jidong, Li Baoshu, Ren Xiaoyong, Shi Ji
Аннотация
OBJECTIVE: To study the expression of eosinophil in nasal polyposis tissue after Bleomycin A5 local injection.
METHOD: Nineteen cases nasal polyposis specimen obtained before and after treatment with Bleomycin A5 were studied with terminal deoxynucleotidyl transferasemediated dUTP nick endlabeling (TUNEL).
RESULT: The number of eosinophil in nasal polyposis specimen before treatment is significantly higher than that after treatment (P<0.01) and so to normal inferior turbinate concha mucosa (P<0.01). The apoptosis index (AI) of eosinophil after treatment is significantly higher than that before treatment (P<0.01).
CONCLUSION: Eosinophil is the main infiltration cell in nasal polyposis tissue. Bleomycin A5 could cure nasal polyposis by promoting eosinophil apoptosis.
METHOD: Nineteen cases nasal polyposis specimen obtained before and after treatment with Bleomycin A5 were studied with terminal deoxynucleotidyl transferasemediated dUTP nick endlabeling (TUNEL).
RESULT: The number of eosinophil in nasal polyposis specimen before treatment is significantly higher than that after treatment (P<0.01) and so to normal inferior turbinate concha mucosa (P<0.01). The apoptosis index (AI) of eosinophil after treatment is significantly higher than that before treatment (P<0.01).
CONCLUSION: Eosinophil is the main infiltration cell in nasal polyposis tissue. Bleomycin A5 could cure nasal polyposis by promoting eosinophil apoptosis.