Медицинская библиотека · Chinese medical journal · 2003

Local tissue hypoxia and formation of nasal polyps.

Jiang Shu, Dong Zhen, Zhu Dongdong, Yang Zhanquan

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Аннотация

OBJECTIVE

To explore the response of nasal mucosa epithelial cells to hypoxia in terms of formation of nasal polyps (NP).

METHODS

Epithelial cells of NP and inferior turbinate (IT) were cultured serum-free under normal oxygen and hypoxic circumstances with stimulation of IL-1 beta and TNF alpha. The vascular endothelial growth factor (VEGF) mRNA and VEGF protein levels of the cultured cells were detected using in situ hybridization and ELISA, respectively.

RESULTS

The expression of VEGF mRNA was significantly higher in epithelial cells of NP than in IT exposed to pro-inflammatory cytokines or hypoxia (P < 0.01). VEGF levels were higher in NP epithelial cells than those of IT (P < 0.01) under hypoxia.

CONCLUSION

VEGF-induced by hypoxia is very important for the early stages of forming polyps.

Для цитирования: Jiang Shu, Dong Zhen, Zhu Dongdong, Yang Zhanquan. Local tissue hypoxia and formation of nasal polyps.. Chinese medical journal. 2003.

Предметные рубрики MeSH

Cell Hypoxia Cells, Cultured Endothelial Growth Factors Enzyme-Linked Immunosorbent Assay Erythropoietin Humans Intercellular Signaling Peptides and Proteins Interleukin-1 Lymphokines Nasal Mucosa Nasal Polyps RNA, Messenger Tumor Necrosis Factor-alpha Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors

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