Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
Long-Term Health-Related Quality of Life in Oropharyngeal Squamous Cell Carcinoma: A Systematic Review.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
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Zarrella Dominique, Chitnis Om, Kim Ha E, Wrozek Taylor, Caraway J Joseph, Levett Paul, Orestes Michael
Аннотация
OBJECTIVE: Although short-term health-related quality of life (HRQoL) outcomes in survivors of oropharyngeal squamous cell carcinoma (OPSCC) are well characterized, long-term HRQoL outcomes (≥5 years posttreatment) are not well established. This systematic review aims to assess long-term HRQoL in OPSCC survivors and identify potential predictors influencing these outcomes.
DATA SOURCES: A comprehensive search of the literature was performed using PubMed, Embase, Web of Science, and Ovid All EBM Reviews (Cochrane).
REVIEW METHODS: Studies met inclusion criteria if they were in English, included OPSCC patients ≥5 years posttreatment, and reported OPSCC-specific HRQoL outcomes measured by validated questionnaires.
RESULTS: The literature search returned 2656 articles for initial review, of which 7 (771 participants, range 9-396) met inclusion criteria. Heterogeneous reporting and lack of raw data precluded meta-analysis. Across validated instruments, survivors demonstrated persistent dysphagia, xerostomia, and diet restriction; however, global HRQoL was generally preserved. Subgroup analyses indicated that single-modality treatment and p16 positivity were associated with better long-term QoL, while advanced stage, base of tongue primary site, chemotherapy use, PEG-tube dependence, smoking or alcohol use at diagnosis, older age, and lower educational attainment predicted poorer QoL outcomes.
CONCLUSION: Long-term OPSCC survivors experience persistent functional impairments despite generally preserved global HRQoL. Standardized, longitudinal studies are needed to better characterize predictors of long-term HRQoL and inform targeted survivorship interventions.
DATA SOURCES: A comprehensive search of the literature was performed using PubMed, Embase, Web of Science, and Ovid All EBM Reviews (Cochrane).
REVIEW METHODS: Studies met inclusion criteria if they were in English, included OPSCC patients ≥5 years posttreatment, and reported OPSCC-specific HRQoL outcomes measured by validated questionnaires.
RESULTS: The literature search returned 2656 articles for initial review, of which 7 (771 participants, range 9-396) met inclusion criteria. Heterogeneous reporting and lack of raw data precluded meta-analysis. Across validated instruments, survivors demonstrated persistent dysphagia, xerostomia, and diet restriction; however, global HRQoL was generally preserved. Subgroup analyses indicated that single-modality treatment and p16 positivity were associated with better long-term QoL, while advanced stage, base of tongue primary site, chemotherapy use, PEG-tube dependence, smoking or alcohol use at diagnosis, older age, and lower educational attainment predicted poorer QoL outcomes.
CONCLUSION: Long-term OPSCC survivors experience persistent functional impairments despite generally preserved global HRQoL. Standardized, longitudinal studies are needed to better characterize predictors of long-term HRQoL and inform targeted survivorship interventions.