Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology · 2000
[The expression of transforming growth factor alpha and its receptor in nasal polyps].
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Chen F Q, Huang W G, Qiao L, Jiang H Y
Аннотация
OBJECTIVE: To assess the possible role of expression of TGF alpha and EGFR in nasal polyps and its relationship with PCNA labeling index.
METHOD: Specimens from 20 patients of nasal polyps were studied with immunohistochemical technique.
RESULT: The expression of TGF alpha, EGFR and PCNA were increased in the epithelium, gland cells and inflammatory cells of nasal polyps. There was a close correlation between the intensities of TGF alpha, EGFR and PCNA.
CONCLUSION: TGF alpha may play a key role in epithelial cell proliferation in nasal polyps.
METHOD: Specimens from 20 patients of nasal polyps were studied with immunohistochemical technique.
RESULT: The expression of TGF alpha, EGFR and PCNA were increased in the epithelium, gland cells and inflammatory cells of nasal polyps. There was a close correlation between the intensities of TGF alpha, EGFR and PCNA.
CONCLUSION: TGF alpha may play a key role in epithelial cell proliferation in nasal polyps.