[The expression of transforming growth factor alpha and its receptor in nasal polyps].

OBJECTIVE

To assess the possible role of expression of TGF alpha and EGFR in nasal polyps and its relationship with PCNA labeling index.

METHOD: Specimens from 20 patients of nasal polyps were studied with immunohistochemical technique.

RESULT: The expression of TGF alpha, EGFR and PCNA were increased in the epithelium, gland cells and inflammatory cells of nasal polyps. There was a close correlation between the intensities of TGF alpha, EGFR and PCNA.

CONCLUSION

TGF alpha may play a key role in epithelial cell proliferation in nasal polyps.