Three cases of allergic dermatitis due to intravesical mitomycin C.

Irritant contact dermatitis has frequently been described in association with mitomycin instillation into the bladder. Three cases of allergic contact dermatitis in which patch tests demonstrated a type IV hypersensitivity reaction are reported. Patients showing skin reaction during mitomycin C vesical instillation should be patch tested to make a decision whether the drug might be continued (toxic reaction) or discontinued (allergic reaction).