Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Boswood Adrian, Gordon Sonya G, Häggström Jens, Vanselow Martin, Wess Gerhard, Stepien Rebecca L, Oyama Mark A, Keene Bruce W, Bonagura John, MacDonald Kristin A, Patteson Mark, Smith Sarah, Fox Philip R, Sanderson Karen, Woolley Richard, Szatmári Viktor, Menaut Pierre, Church Whitney M, O'Sullivan M Lynne, Jaudon Jean-Philippe, Kresken Jan-Gerd, Rush John, Barrett Kirstie A, Rosenthal Steven L, Saunders Ashley B, Ljungvall Ingrid, Deinert Michael, Bomassi Eric, Estrada Amara H, Fernandez Del Palacio Maria J, Moise N Sydney, Abbott Jonathan A, Fujii Yoko, Spier Alan, Luethy Michael W, Santilli Roberto A, Uechi Masami, Tidholm Anna, Schummer Christoph, Watson Philip
Аннотация
OBJECTIVES: To describe the changes in clinical and radiographic variables occurring as dogs with MMVD and cardiomegaly develop CHF, compared to similar dogs that do not develop CHF.
ANIMALS: One hundred and thirty-five, and 73 dogs that did or did not develop CHF, respectively.
MATERIALS AND METHODS: The following variables were evaluated in 2 groups of dogs (dogs that did or did not develop CHF): Heart rate (HR), clinic respiratory rate (RR), home-measured resting respiratory rate (RRR), rectal temperature (RT), body weight (BW), and vertebral heart sum (VHS). Absolute value and rate of change of each variable were calculated for each day a dog was in study. Daily means were calculated and plotted against time. The onset of CHF or last visit before leaving the study were set as reference time points.
RESULTS: The most extreme values and rate of change occurred in variables immediately before onset of CHF. Vertebral heart sum increased earliest. Heart rate, RR, and RRR also increased. Rectal temperature and BW decreased. Increases in RR and RRR were most extreme and occurred immediately before CHF.
CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with MMVD and cardiomegaly experience increases in HR, RR, RRR, and VHS, and decreases in BW and RT as they develop CHF. The variables with highest absolute change and rate of change were RR and RRR. These findings reinforce the value of RR and RRR as indicators of impending or incipient CHF.