[Advanced research in the safety of UVA-riboflavin cross-linking for strengthening corneal and scleral tissue].

UVA-riboflavin cross-linking is an effective approach to increase the mechanical and biochemical rigidity of the collagen fiber, which has been used in treating some corneal diseases such as keratoconus, and might become a new treatment modality for strengthening scleral tissue to prevent progressive myopia, so the safety of the new therapy has be paid attention widely. This article focus on the diffusion process and saturation judgment of riboflavin and describes the effect of riboflavin, direct UV damage, photochemical damage and the prevention of side effects in cross-linking therapy.