An evaluation framework for clinical use of large language models in patient interaction tasks.

The integration of large language models (LLMs) into clinical diagnostics has the potential to transform doctor-patient interactions. However, the readiness of these models for real-world clinical application remains inadequately tested. This paper introduces the Conversational Reasoning Assessment Framework for Testing in Medicine (CRAFT-MD) approach for evaluating clinical LLMs. Unlike traditional methods that rely on structured medical examinations, CRAFT-MD focuses on natural dialogues, using simulated artificial intelligence agents to interact with LLMs in a controlled environment. We applied CRAFT-MD to assess the diagnostic capabilities of GPT-4, GPT-3.5, Mistral and LLaMA-2-7b across 12 medical specialties. Our experiments revealed critical insights into the limitations of current LLMs in terms of clinical conversational reasoning, history-taking and diagnostic accuracy. These limitations also persisted when analyzing multimodal conversational and visual assessment capabilities of GPT-4V. We propose a comprehensive set of recommendations for future evaluations of clinical LLMs based on our empirical findings. These recommendations emphasize realistic doctor-patient conversations, comprehensive history-taking, open-ended questioning and using a combination of automated and expert evaluations. The introduction of CRAFT-MD marks an advancement in testing of clinical LLMs, aiming to ensure that these models augment medical practice effectively and ethically.