Journal of Alzheimer's disease : JAD · 2016
Association of Frontotemporal Dementia GWAS Loci with Late-Onset Alzheimer's Disease in a Northern Han Chinese Population.
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Tan Chen-Chen, Wan Yu, Tan Meng-Shan, Zhang Wei, Wang Zi-Xuan, Sun Fu-Rong, Miao Dan, Tan Lan, Yu Jin-Tai
Аннотация
BACKGROUND: Both Alzheimer's disease (AD) and frontotemporal dementia (FTD) are a class of neurodegenerative diseases. Strong similarities in cerebrospinal fluid biomarker, imaging markers, and disease progression profiles suggest that some or most of the pathophysiology is shared between AD and FTD. A recent large genome-wide association study reported several single nucleotide polymorphisms (SNPs) at the RAB38, RAB38/CTSC, HLA-DRA/HLA-DRB5, and BTNL2 in association with FTD.
OBJECTIVE: To explore whether these SNPs are associated with AD risk.
METHODS: We conducted a case-control study to investigate the association of FTD-associated loci in 2338 Han Chinese subjects.
RESULTS: We observed significant differences in genotype distributions of rs302668 (pc = 0.025), rs9268877 (pc = 0.025), rs9268856 (p < 0.001), and rs1980493 (pc = 0.045) between cases and controls. The SNPs rs16913634 for RAB38/CTSC was unrelated to LOAD risk (p = 0.088).
CONCLUSION: The SNPs rs302668 in RAB38, rs9268877 and rs9268856 polymorphism in HLA-DRA/HLA-DRB5, and rs1980493 polymorphism in BTNL2 might play a role in the susceptibility to late-onset AD in the Han Chinese population.
OBJECTIVE: To explore whether these SNPs are associated with AD risk.
METHODS: We conducted a case-control study to investigate the association of FTD-associated loci in 2338 Han Chinese subjects.
RESULTS: We observed significant differences in genotype distributions of rs302668 (pc = 0.025), rs9268877 (pc = 0.025), rs9268856 (p < 0.001), and rs1980493 (pc = 0.045) between cases and controls. The SNPs rs16913634 for RAB38/CTSC was unrelated to LOAD risk (p = 0.088).
CONCLUSION: The SNPs rs302668 in RAB38, rs9268877 and rs9268856 polymorphism in HLA-DRA/HLA-DRB5, and rs1980493 polymorphism in BTNL2 might play a role in the susceptibility to late-onset AD in the Han Chinese population.
Предметные рубрики MeSH
Age of OnsetAgedAlzheimer DiseaseApolipoprotein E4Asian PeopleCase-Control StudiesChinaFemaleFrontotemporal DementiaGene FrequencyGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeGenotyping TechniquesHumansLinkage DisequilibriumMaleMental Status SchedulePolymorphism, Single Nucleotide