Dementia and geriatric cognitive disorders extra · 2015
Hypertensive Disorders of Pregnancy Appear Not to Be Associated with Alzheimer's Disease Later in Life.
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Abheiden Carolien N H, van Doornik Rebecca, Aukes Annet M, van der Flier Wiesje M, Scheltens Philip, de Groot Christianne J M
Аннотация
BACKGROUND: After hypertensive disorders of pregnancy, more subjective cognitive complaints and white matter lesions are reported compared to women after normal pregnancies. Both have a causal relationship with Alzheimer's disease (AD).
AIM: To investigate if women whose pregnancy was complicated by hypertensive disorders have an increased risk of AD.
METHODS: A case-control study in women with AD from the Alzheimer Center of the VU University Medical Center Amsterdam and women without AD. Paper and telephone surveys were performed.
RESULTS: The response rate was 85.2%. No relation between women with (n = 104) and without AD (n = 129) reporting pregnancies complicated by hypertensive disorders (p = 0.11) was found. Women with early-onset AD reported hypertensive disorders of pregnancy more often (p = 0.02) compared to women with late-onset AD.
CONCLUSION: A reported history of hypertensive disorders of pregnancy appears not to be associated with AD later in life.
AIM: To investigate if women whose pregnancy was complicated by hypertensive disorders have an increased risk of AD.
METHODS: A case-control study in women with AD from the Alzheimer Center of the VU University Medical Center Amsterdam and women without AD. Paper and telephone surveys were performed.
RESULTS: The response rate was 85.2%. No relation between women with (n = 104) and without AD (n = 129) reporting pregnancies complicated by hypertensive disorders (p = 0.11) was found. Women with early-onset AD reported hypertensive disorders of pregnancy more often (p = 0.02) compared to women with late-onset AD.
CONCLUSION: A reported history of hypertensive disorders of pregnancy appears not to be associated with AD later in life.