Journal of the science of food and agriculture · 2025
Anserine alleviates atherosclerosis in ApoE-/- mice by regulating lipid metabolism.
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Luo Jing, Chen Ming, Ji Hongwu, Zhang Di, Su Weiming, Liu Shucheng
Аннотация
BACKGROUND: Anserine is a bioactive and nutritional food supplement, widely used in the food health supplement, athletic nutrition, and medical fields. The aim was to investigate the mechanism of anserine in alleviating atherosclerosis. ApoE-/- mice were fed a high-fat diet and orally administered anserine at doses of 30, 60, and 120 mg kg-1 d-1 for 16 weeks.
RESULTS: Anserine showed the effect of inhibiting the synthesis of low-density lipoprotein cholesterol based on reduced Surfeit 4 (Surf4) expression levels in the liver. Anserine showed the effect of accelerating cholesterol metabolism based on increased scavenger receptor class B type (SR-B1), cholesterol 7α-hydroxylase (CYP7A1), cholesterol 27α-hydroxylase (CYP27A1), and ATP-binding cassette subfamily G member 8 (ABCG8) expression levels in the liver. Anserine exhibited the effect of inhibiting exogenous cholesterol absorption based on reduced hepatocyte nuclear factor 4 alpha (HNF-4α)-Niemann-Pick C1-Like 1 (NPC1L1)-Gramd1b/Gramd1c expression levels in small intestine. Correlation analysis showed that the plaque area was positively correlated with the Surf4 and NPC1L1, and negatively correlated with CYP7A1.
CONCLUSION: These results suggested that anserine might be a novel strategy to alleviate atherosclerosis by regulating lipid metabolism. © 2025 Society of Chemical Industry.
RESULTS: Anserine showed the effect of inhibiting the synthesis of low-density lipoprotein cholesterol based on reduced Surfeit 4 (Surf4) expression levels in the liver. Anserine showed the effect of accelerating cholesterol metabolism based on increased scavenger receptor class B type (SR-B1), cholesterol 7α-hydroxylase (CYP7A1), cholesterol 27α-hydroxylase (CYP27A1), and ATP-binding cassette subfamily G member 8 (ABCG8) expression levels in the liver. Anserine exhibited the effect of inhibiting exogenous cholesterol absorption based on reduced hepatocyte nuclear factor 4 alpha (HNF-4α)-Niemann-Pick C1-Like 1 (NPC1L1)-Gramd1b/Gramd1c expression levels in small intestine. Correlation analysis showed that the plaque area was positively correlated with the Surf4 and NPC1L1, and negatively correlated with CYP7A1.
CONCLUSION: These results suggested that anserine might be a novel strategy to alleviate atherosclerosis by regulating lipid metabolism. © 2025 Society of Chemical Industry.
Предметные рубрики MeSH
AnimalsAtherosclerosisCholesterol 7-alpha-HydroxylaseMiceLipid MetabolismMaleLiverApolipoproteins ECholesterolHumansDiet, High-FatMice, Inbred C57BLCholestanetriol 26-MonooxygenaseATP Binding Cassette Transporter, Subfamily G, Member 8Mice, KnockoutCholesterol, LDLHepatocyte Nuclear Factor 4Scavenger Receptors, Class BMembrane ProteinsDietary Supplements