Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry · 2025
Unusual Oral Presentations of Herpes Simplex Virus-1: A Series of Eight Cases and Literature Review.
СтатьяОбзорКлинический случайНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
de Paiva João Paulo Gonçalves, Sousa-Neto Sebastião Silvério, Humberto Maurilo Antônio Correia, Magalhães Marco Antônio de Oliveira, Bubola Justin, Assunção Júnior José Narciso Rosa, Marcucci Marcelo, Sena-Filho Marcondes, Lemos Celso Augusto, Saldivia-Siracusa Cristina, Santos-Silva Alan Roger, Jorge Jacks, Vargas Pablo Agustin
Аннотация
AIMS: The aim of this study is to characterize the clinical and microscopic features of recurrent oral/labial HSV-1 infection with unusual clinical presentations.
METHODS: A literature review and retrospective case series of patients with recurrent oral/labial HSV-1 with unusual presentations were conducted. Data were collected from medical records, and all cases were confirmed by histopathology and immunohistochemistry.
RESULTS: Eight patients (five males, 62.5%; three females, 37.5%) with a mean age of 61.8 years presented with unusual HSV-1 manifestations, including solitary lesions, white plaque-like appearance, non-keratinized site involvement, or prolonged duration. Lesions involved the tongue border (n = 4, 50%), anterior ventral tongue, hard palate, posterior ridge crest, and lower lip (n = 1, 12.5% each). Presented as well-demarcated solitary ulcers (n = 6, 75%), solitary papule (n = 1, 12.5%), and whitish plaque-like lesions (n = 1, 12.5%). Only two patients were immunosuppressed. All cases responded successfully to management, including pharmacotherapy, surgical excision, or photobiomodulation. Unusual clinical presentations of oral/labial HSV-1 infection are scarcely reported in the literature.
CONCLUSION: Unusual HSV-1 manifestations can occur in immunocompetent individuals; however, exclusion of undiagnosed immunosuppression remains necessary. A definitive diagnosis relies on careful histopathological evaluation of ulcer edges, which is crucial for guiding appropriate treatment. Further documentation of similar cases is essential to reinforce that these unusual presentations can indeed affect immunocompetent patients.
METHODS: A literature review and retrospective case series of patients with recurrent oral/labial HSV-1 with unusual presentations were conducted. Data were collected from medical records, and all cases were confirmed by histopathology and immunohistochemistry.
RESULTS: Eight patients (five males, 62.5%; three females, 37.5%) with a mean age of 61.8 years presented with unusual HSV-1 manifestations, including solitary lesions, white plaque-like appearance, non-keratinized site involvement, or prolonged duration. Lesions involved the tongue border (n = 4, 50%), anterior ventral tongue, hard palate, posterior ridge crest, and lower lip (n = 1, 12.5% each). Presented as well-demarcated solitary ulcers (n = 6, 75%), solitary papule (n = 1, 12.5%), and whitish plaque-like lesions (n = 1, 12.5%). Only two patients were immunosuppressed. All cases responded successfully to management, including pharmacotherapy, surgical excision, or photobiomodulation. Unusual clinical presentations of oral/labial HSV-1 infection are scarcely reported in the literature.
CONCLUSION: Unusual HSV-1 manifestations can occur in immunocompetent individuals; however, exclusion of undiagnosed immunosuppression remains necessary. A definitive diagnosis relies on careful histopathological evaluation of ulcer edges, which is crucial for guiding appropriate treatment. Further documentation of similar cases is essential to reinforce that these unusual presentations can indeed affect immunocompetent patients.