The Journal of emergency medicine · 2026
Depression's Association with Major Adverse Cardiac Events in Patients with Low-Risk Chest Pain.
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Akkad Amer, Drabish Kerry, Thompson Stephanie, Hunt Amy
Аннотация
BACKGROUND: Depression has been identified as an independent risk factor for cardiovascular disease (CVD) development and poor prognosis. However, minimal research on depression's role in CVD has focused on low-risk patients reporting chest pain, a symptom of somatic depression presentation or possible acute coronary syndrome.
OBJECTIVE(S): Thus, our study determined if documented depression was associated with short-term (30 days and 90 days) major adverse cardiac events (MACE) and emergency department (ED) revisit rates.
METHODS: We conducted a retrospective review using abstracted data of 4993 adults who presented to the ED over a 5-year period, complaining of chest pain and deemed low risk by HEART scores <4.
RESULTS: Patients with depression had significantly higher frequencies of 30-day (0.8% vs. 0.2%, p = 0.003) and 90-day MACE (2.1% vs. 0.8%, p < 0.001) compared to patients without depression. In multivariate analysis allowing for the control of confounders, depression (odds ratio [OR] 5.000, confidence interval [CI] 2.614-9.565) and age (OR 1.071, CI 1.047-1.096) predicted 90-day MACE. Rates of ED revisits were higher in patients with depression at 30 days (7.8% vs. 3.3%, p < 0.001) and 90 days (38.8% vs. 19.4%, p < 0.001).
CONCLUSION: Thus, low-risk patients with depression had elevated rates of short-term MACE and ED utilization.
OBJECTIVE(S): Thus, our study determined if documented depression was associated with short-term (30 days and 90 days) major adverse cardiac events (MACE) and emergency department (ED) revisit rates.
METHODS: We conducted a retrospective review using abstracted data of 4993 adults who presented to the ED over a 5-year period, complaining of chest pain and deemed low risk by HEART scores <4.
RESULTS: Patients with depression had significantly higher frequencies of 30-day (0.8% vs. 0.2%, p = 0.003) and 90-day MACE (2.1% vs. 0.8%, p < 0.001) compared to patients without depression. In multivariate analysis allowing for the control of confounders, depression (odds ratio [OR] 5.000, confidence interval [CI] 2.614-9.565) and age (OR 1.071, CI 1.047-1.096) predicted 90-day MACE. Rates of ED revisits were higher in patients with depression at 30 days (7.8% vs. 3.3%, p < 0.001) and 90 days (38.8% vs. 19.4%, p < 0.001).
CONCLUSION: Thus, low-risk patients with depression had elevated rates of short-term MACE and ED utilization.