Future oncology (London, England) · 2015
Efficacy of radioembolization according to tumor morphology and portal vein thrombosis in intermediate-advanced hepatocellular carcinoma.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Golfieri Rita, Mosconi Cristina, Cappelli Alberta, Giampalma Emanuela, Galaverni Maria Cristina, Pettinato Cinzia, Renzulli Matteo, Monari Fabio, Angelelli Bruna, Pini Patrizia, Terzi Eleonora, Ascanio Salvatore, Garzillo Giorgio, Piscaglia Fabio, Bolondi Luigi, Trevisani Franco
Аннотация
PURPOSE: We analyzed overall survival (OS) following radioembolization according to macroscopic growth pattern (nodular vs infiltrative) and vascular invasion in intermediate-advanced hepatocellular carcinoma (HCC).
METHODS: Between September 2005 and November 2013, 104 patients (50.0% portal vein thrombosis [PVT], 29.8% infiltrative morphology) were treated.
RESULTS: Median OS differed significantly between patients with segmental and lobar or main PVT (p = 0.031), but was 17 months in both those with patent vessels and segmental PVT. Median OS did not differ for infiltrative and nodular HCC. Median OS was prolonged in patients with a treatment response at 3 months (p = 0.023). Prior TACE was also a significant predictor of improved OS.
CONCLUSION: A further indication for radioembolization might be infiltrative HCC, since OS was similar to nodular types.
METHODS: Between September 2005 and November 2013, 104 patients (50.0% portal vein thrombosis [PVT], 29.8% infiltrative morphology) were treated.
RESULTS: Median OS differed significantly between patients with segmental and lobar or main PVT (p = 0.031), but was 17 months in both those with patent vessels and segmental PVT. Median OS did not differ for infiltrative and nodular HCC. Median OS was prolonged in patients with a treatment response at 3 months (p = 0.023). Prior TACE was also a significant predictor of improved OS.
CONCLUSION: A further indication for radioembolization might be infiltrative HCC, since OS was similar to nodular types.
Предметные рубрики MeSH
AdultAgedAged, 80 and overCarcinoma, HepatocellularChemoembolization, TherapeuticCombined Modality TherapyFemaleHumansKaplan-Meier EstimateLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPortal VeinRadiopharmaceuticalsRetrospective StudiesTomography, X-Ray ComputedTreatment OutcomeTumor BurdenVenous ThrombosisYoung AdultYttrium Radioisotopes