Recurrent pregnancy loss and thyroid autoimmunity: A review of mechanisms and clinical management.

As a major challenge currently plaguing reproductive medicine, recurrent pregnancy loss(RPL) has a variety of causes. Thyroid autoimmunity(TAI) is a prevalent thyroid disorder among women of childbearing age, potentially impacting maternal physiological changes and the balance of the maternal-fetal interface during pregnancy through endocrine and autoimmune pathways, which can lead to abortion and RPL. The selection of therapeutic agents and the effectiveness of treatment for patients experiencing RPL with thyroid autoimmunity remain contentious. Current research have explored the efficacy of medications such as levothyroxine, immunoglobulins, glucocorticoids, cyclosporine, hydroxychloroquine, selenium, and vitamin D for these patients. This review summarizes the correlation between TAI and RPL, as well as the current status of its diagnosis and treatment, with the aim of providing new ideas for clinical diagnosis and treatment.