PECULIARITIES OF REMODELING OF HEART AND NEUROHUMORAL STATUS IN PATIENTS WITH CHRONIC HEART FAILURE AND CONCOMITANT RENAL DISEASE DEPENDING ON THE VALUE OF THE EJECTION FRACTION OF THE LEFT VENTRICLE.

67 patients with CHF of FC II and concomitant chronic pyelonephritis at remission stage for not less than 6 months. As of the screening moment, intervention group (n=67 patients) and control group (n=22 apparently healthy individuals) were formed. The intervention group was divided into 3 groups: group 1 included 22 CHF patients with preserved LV EF (≥50%) associated with AH and concomitant CRD. Group 2 included 23 CHF patients with decreased heart LV EF (≤40%, but not less than 35%) associated with AH and concomitant CRD. Group 3 was comprised of 22 patients with CHF associated with AH and concomitant CRD, having LV EF 40-49% (so-called "medium" LV EF). In order to evaluate the condition of RAAS regulators, plasma aldosterone level (PA) and plasma renin activity level (PRA) were studied. The ultrasonic parameters were measured in order to determine structural-functional condition of the heart. the study of structural-functional condition of heart, taking into account both systolic and diastolic function of the left ventricle of heart, comparison of parameters in CHF patients associated with AH and CRD with preserved LV EF and "medium" LV EF, PA (by 31.28%) and decrease of PRA parameter (by 14.5%) in the group of CHF patients associated with AH and CRD with "medium" LV EF. Comparison of the groups of CHF patients associated with AH and CRD with decreased LV EF and "medium" LV EF has identified the increase of such parameters as relative wall thickness index (by 2.13%), MMI (by 6.13%), PA (by 22.4%); besides, the increase of Е/е parameter (by 2.7%) was identified in the group of CHF patients with "medium" LV EF.