Acta neurologica Scandinavica · 1997
Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Caraceni A, Martini C, Spatti G, Thomas A, Onofrj M
Аннотация
INTRODUCTION: We describe bilateral optic neuropathy in a patient affected by ovarian carcinoma treated with cis-platin 160 mg/m2 and carboplatin, 640 mg/m2. The patient was followed for 1 year, when recovery appeared. The few previous descriptions of CDDP optic nerve toxicity did not report recovery.
METHODS: Computerized visual field, visual evoked potentials, pattern electroretinograms, full field flash electroretinograms were recorded during follow-up.
RESULTS: Optic neuritis appeared 13 weeks after cis-platin discontinuation, with right eye central scotoma; 2 days later the patient became bilaterally blind. Visual evoked potentials were initially absent, reappeared, with delayed latencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eye.
CONCLUSION: Cis-platin can induce delayed optic neuritis, that can recover in 1 year.
METHODS: Computerized visual field, visual evoked potentials, pattern electroretinograms, full field flash electroretinograms were recorded during follow-up.
RESULTS: Optic neuritis appeared 13 weeks after cis-platin discontinuation, with right eye central scotoma; 2 days later the patient became bilaterally blind. Visual evoked potentials were initially absent, reappeared, with delayed latencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eye.
CONCLUSION: Cis-platin can induce delayed optic neuritis, that can recover in 1 year.
Предметные рубрики MeSH
Antineoplastic AgentsCarboplatinChemotherapy, AdjuvantCisplatinCystadenocarcinoma, PapillaryDose-Response Relationship, DrugDrug Administration ScheduleEvoked Potentials, VisualFemaleFollow-Up StudiesHumansMiddle AgedOptic NerveOptic NeuritisOvarian NeoplasmsRemission, SpontaneousSubstance Withdrawal SyndromeVisual Acuity