Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2024
The Role of BDNF in the Antidepressant Effects of Electroconvulsive Therapy.
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Ushakova V M, Zubkov E A, Morozova A Yu, Pavlov K A, Zorkina Ya A, Abramova O V, Ochneva A G, Gurina O I, Tarkovskaya K Sh, Inozemtsev A N, Chekhonin V P
Аннотация
Electroconvulsive therapy (ECT) is an effective treatment method for depression therapy. It produces a number of biological effects, including neurotrophic factors regulation. In the present paper, we investigated the ECT response in depressed rats subjected to the variable frequency ultrasound (20-45 kHz) and examined the contribution of brain-derived neurotrophic factor (BDNF) expression changes to the observed effects. The obtained results reflect the therapeutic potential of ECT for the treatment of depressive-like state in rodents and indicate the role of BDNF in these processes. In future research, it is necessary to investigate the relationship between neurotrophin and structural changes and to study other neurotrophic biomarkers that may be associated with the development of depression-like state and the therapy response.