CNS neuroscience & therapeutics · 2016
Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Luca Giovanni, Bellezza Ilaria, Arato Iva, Di Pardo Alba, Mancuso Francesca, Calvitti Mario, Falabella Giulia, Bartoli Sara, Maglione Vittorio, Amico Enrico, Favellato Mariagrazia, Basta Giuseppe, Bodo Maria, Minelli Alba, Calafiore Riccardo, Frati Luigi, Squitieri Ferdinando
Аннотация
INTRODUCTION: Immune dysfunction, promoted by pro-inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease.
AIMS: The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease.
METHODS: The experimental R6/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated.
RESULTS: The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6/2 Huntington's disease mice, by immune dysfunction modulation in brain.
CONCLUSIONS: This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.
AIMS: The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease.
METHODS: The experimental R6/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated.
RESULTS: The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6/2 Huntington's disease mice, by immune dysfunction modulation in brain.
CONCLUSIONS: This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.
Предметные рубрики MeSH
AnimalsAnimals, NewbornApoptosisCorpus StriatumCyclooxygenase 2CytokinesDisease Models, AnimalDrug CompoundingFemaleGene Expression RegulationHumansHuntingtin ProteinHuntington DiseaseMaleMiceMice, TransgenicMotor ActivityNitric Oxide Synthase Type IISertoli CellsSurvival AnalysisSwineTrinucleotide Repeats