Медицинская библиотека · CNS neuroscience & therapeutics · 2016

Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease.

Luca Giovanni, Bellezza Ilaria, Arato Iva, Di Pardo Alba, Mancuso Francesca, Calvitti Mario, Falabella Giulia, Bartoli Sara, Maglione Vittorio, Amico Enrico, Favellato Mariagrazia, Basta Giuseppe, Bodo Maria, Minelli Alba, Calafiore Riccardo, Frati Luigi, Squitieri Ferdinando

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

INTRODUCTION

Immune dysfunction, promoted by pro-inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease.

AIMS: The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease.

METHODS

The experimental R6/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated.

RESULTS

The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6/2 Huntington's disease mice, by immune dysfunction modulation in brain.

CONCLUSIONS

This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.

Для цитирования: Luca Giovanni, Bellezza Ilaria, Arato Iva, Di Pardo Alba, Mancuso Francesca, Calvitti Mario, Falabella Giulia, Bartoli Sara, Maglione Vittorio, Amico Enrico, Favellato Mariagrazia, Basta Giuseppe, Bodo Maria, Minelli Alba, Calafiore Riccardo, Frati Luigi, Squitieri Ferdinando. Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease.. CNS neuroscience & therapeutics. 2016. DOI: 10.1111/cns.12569.

Предметные рубрики MeSH

Подготовка и перевод публикации

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.