Wiadomosci lekarskie (Warsaw, Poland : 1960) · 2025
Evaluation of serum Neopterin levels in patients with type 2 diabetes mellitus and hypothyroidism.
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Tahir Noor Thair, Tuama Riyam Hassan, Kasim Hala Fouad, Akram Raghda Shams, Al-Auqbi Tawfeeq F R
Аннотация
OBJECTIVE: Aim: This study aims to investigate the variation in serum Neopterin levels between adult individuals (T2DM with hypothyroidism and without hypothyroidism).
PATIENTS AND METHODS: Materials and Methods: Ninety participants were divided into three group: 30 patients with T2DM and hypothyroidism, 30 patients with T2DM and without hypothyroidism and 30 Control patients. They were obtained from national diabetes center, Mustansiriyah University.
RESULTS: Results: The current findings have found that patients in Group I (T2DM with hypothyroidism) showed significantly raised neopterin levels (614.87 ± 166.27 pg/ml) as compared to Group II (T2DM without hypothyroidism) which is (335.27 ± 173.34 pg/ml) and healthy control group (267.29 ± 254.4 pg/ml). The level of neopterin in T2DM with hypothyroidism patients, and T2DM without hypothyroidism patients have a significant (P<0.05) positive correlation coefficient with BMI, HbA1c, TC, TG, AIP and TSH. Furthermore, a high significant (P<0.01) positive correlation with FBS, HOMA-IR and LDL-C was also found.
CONCLUSION: Conclusions: The elevated levels of neopterin in type 2 diabetic patients with hypothyroidism and without hypothyroidism play as a regulator of energy consumption, leading to the hypothesis that thyroid gland disease may influence its level. In addition, the potential for use as a diagnostic marker for diabetics with thyroid disease due to the occurrence of complications of diabetes, including cardiovascular diseases.
PATIENTS AND METHODS: Materials and Methods: Ninety participants were divided into three group: 30 patients with T2DM and hypothyroidism, 30 patients with T2DM and without hypothyroidism and 30 Control patients. They were obtained from national diabetes center, Mustansiriyah University.
RESULTS: Results: The current findings have found that patients in Group I (T2DM with hypothyroidism) showed significantly raised neopterin levels (614.87 ± 166.27 pg/ml) as compared to Group II (T2DM without hypothyroidism) which is (335.27 ± 173.34 pg/ml) and healthy control group (267.29 ± 254.4 pg/ml). The level of neopterin in T2DM with hypothyroidism patients, and T2DM without hypothyroidism patients have a significant (P<0.05) positive correlation coefficient with BMI, HbA1c, TC, TG, AIP and TSH. Furthermore, a high significant (P<0.01) positive correlation with FBS, HOMA-IR and LDL-C was also found.
CONCLUSION: Conclusions: The elevated levels of neopterin in type 2 diabetic patients with hypothyroidism and without hypothyroidism play as a regulator of energy consumption, leading to the hypothesis that thyroid gland disease may influence its level. In addition, the potential for use as a diagnostic marker for diabetics with thyroid disease due to the occurrence of complications of diabetes, including cardiovascular diseases.