THE STATE OF LOCAL IMMUNITY IN PERSONS WITH PERIODONTAL DISEASES ON A BACKGROUND OF DIFFERENT PHYCHOPHYSIOLOGICAL REACTIONS OF MALADAPTATION.

The objective of the study was to determine the changes of local immunity indicators in persons with periodontal diseases and the influence of psychophysiological state on their activity. The study involved 130 patients 19-44-years old with periodontal diseases on a background of different psychophysiological reactions of maladaptation. Two study groups were formed: І group - 73 persons with gingivitis; ІІ group - 57 persons with chronic generalized periodontitis. For psychophysiological examination we used Raven's Progressive Matrices test. The average content of sIgA in persons of group I by 14.22% exceeded the corresponding data in persons of group II. The IgA concentration in group I was 0.191±0.004 g/l, which was 6.42% higher than in group II - 0.172±0.006 g/l, p>0.05. IgG content in group I exceeded by 15.54% the corresponding data in group II. Average data of lysozyme content in group I was 6.87% higher than in group II (427.0±5.20 μg/ml vs. 397.00±4.24 μg/ml, p<0, 01). The dynamics of immunoglobulins and lysozyme in the oral fluid of the study groups, depending on the psychophysiological state of the organism were determined and analyzed. Certain imbalance of local protection factors (lysozyme and sIgA) and the concentration of immunoglobulins A and G was characterized by a decrease in the values of the indices with deepening of psychophysiological reactions of maladaptation, and this tendency was more pronounced in patients with chronic generalized periodontitis.