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Войти в исследования Journal of neuro-oncology · 2026
Visual outcomes of sight threatening radiation-induced meningiomas after low-dose head irradiation: tinea capitis as a paradigm.
СтатьяНазвание и аннотация: Перевод в очереди
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Palevski Dahlia, Stiebel-Kalish Hadas, Bialer Omer Yizhach
Аннотация
PURPOSE: To investigate the visual characteristics and prognosis of vision-threatening meningiomas following low dose head radiation and compare them to those of primary unexposed meningiomas.
METHODS: A retrospective cohort of adults with meningiomas adjacent to the optic nerves or intracranial visual pathways was categorized into radiation-exposed and unexposed meningiomas. Data collected included demographics, visual biomarkers at presentation and at final follow-up, including Visual Acuity (VA), color vision (CV), Visual Field (VF) and peripapillary Retinal Nerve Fiber Layer (RNFL) thickness via Optical coherence tomography (OCT). Comparative analyses were performed between radiation-exposed and unexposed cohorts.
RESULTS: 289 eligible patients seen between 2004 and 2023 were included, out of which 31 (10.7%) had undergone tinea capitis radiation. At presentation, patients exhibited a median BCVA of 0.1 LogMAR [IQR 0.1-0.6], median CV of 100% [IQR 64.5%-100%], and 9 (29%) had normal visual fields. Notably, 16 (51.61%) experienced visual loss. Their BCVA decreased at final follow-up, to median 0.23 [IQR 0.1-1.46]. Comparative analysis with 114 radiation-naïve patients with meningioma-induced visual loss revealed no statistically significant disparities in visual characteristics at presentation or at follow-up.
CONCLUSIONS: No statistically significant differences in clinical presentation or visual prognosis were detected between patients with visual pathway meningiomas exposed to low-dose childhood radiation and radiation-naïve patients. Since low-dose cranial irradiation continues to be widely used for conditions such as thyroid eye disease, our findings are relevant beyond the specific context of tinea capitis.
METHODS: A retrospective cohort of adults with meningiomas adjacent to the optic nerves or intracranial visual pathways was categorized into radiation-exposed and unexposed meningiomas. Data collected included demographics, visual biomarkers at presentation and at final follow-up, including Visual Acuity (VA), color vision (CV), Visual Field (VF) and peripapillary Retinal Nerve Fiber Layer (RNFL) thickness via Optical coherence tomography (OCT). Comparative analyses were performed between radiation-exposed and unexposed cohorts.
RESULTS: 289 eligible patients seen between 2004 and 2023 were included, out of which 31 (10.7%) had undergone tinea capitis radiation. At presentation, patients exhibited a median BCVA of 0.1 LogMAR [IQR 0.1-0.6], median CV of 100% [IQR 64.5%-100%], and 9 (29%) had normal visual fields. Notably, 16 (51.61%) experienced visual loss. Their BCVA decreased at final follow-up, to median 0.23 [IQR 0.1-1.46]. Comparative analysis with 114 radiation-naïve patients with meningioma-induced visual loss revealed no statistically significant disparities in visual characteristics at presentation or at follow-up.
CONCLUSIONS: No statistically significant differences in clinical presentation or visual prognosis were detected between patients with visual pathway meningiomas exposed to low-dose childhood radiation and radiation-naïve patients. Since low-dose cranial irradiation continues to be widely used for conditions such as thyroid eye disease, our findings are relevant beyond the specific context of tinea capitis.