[The new psychopathological paradigm of schizophrenia and schizophrenia spectrum disorders].

The basis of the new paradigm, as an attempt to modernize the systematics of psychopathological disorders, is the concept of simultaneous representation of two relatively independent domains (founded by neurobiological processes) in the clinical space of schizophrenia - negative and positive disorders. The study established the spectra of functional activity of endogenous dimensions, as well as the trajectories of their development, which determine the dominance of predominantly negative or positive symptoms (negative/positive schizophrenia) during the course of the disease. The differentiated impact of endogenous domains on constitutional characterological structures accompanied by the formation of pseudopsychiopathies and subpsychotic personality disorders is observed.