Circadian characteristic of kidney excretory function influenced by nitrogen monoxide synthesis blockade under conditions of pineal gland normal with peculiarities of melatonin effect.

OBJECTIVE

The features of сhronorhythmic alterations of excretory renal function under the physiological conditions of the pineal gland (PG) under the influence of a blockade of synthesis of nitrogen monoxide (NO) and melatonin correction were investigated. The aim: Aim of our work was to investigate circadian characteristic of kidney excretory function influenced by nitrogen monoxide synthesis blockade under conditions of pineal gland normal with peguliarities of melatonin effect.

PATIENTS AND

METHODS

Materials and methods: The experiments were conducted on 72 mature non-linear albino male rats with their body mass 0,15-0,18 kg. The animals were kept under vivarium conditions at a stable temperature and air humidity fed on a standard dietary intake.

RESULTS

Results and conclusions: Based on a series of studies, the blockade of NO synthesis and melatonin correction resulted in a decrease in the average daily urinary output and a decrease in the removal of potassium ions from urine, relative to control, during the observation period. Therefore, the clarification of the features of сhronorhythmic alterations of the excretory renal function under the physiological conditions of the PG under the influence of blockade of NO synthesis and melatonin correction is important for the knowledge of the mechanisms of occurrence and development of pathological conditions, which will enable to improve the early diagnosis, improve the treatment of renal pathology and timely preventative measures.