Obesity and the Risk of Cryptogenic Ischemic Stroke in Young Adults.
Обработка статьи · этапы, ошибки и управление
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Jaakonmäki Nina, Zedde Marialuisa, Sarkanen Tomi, Martinez-Majander Nicolas, Tuohinen Suvi, Sinisalo Juha, Ryödi Essi, Autere Jaana, Hedman Marja, Junttola Ulla, Huhtakangas Jaana K, Grimaldi Teresa, Pascarella Rosario, Nordanstig Annika, Bech-Hanssen Odd, Holbe Christine, Busch Raila, Fromm Annette, Ylikotila Pauli, Turgut Esme Ekizoglu, Amorim Isabel, Ryliskiene Kristina, Tulkki Lauri, Pascasio Laura Amaya, Licenik Radim, Ferdinand Phillip, Tsivgoulis Georgios, Jatužis Dalius, Kõrv Liisa, Kõrv Janika, Pezzini Alessandro, Fonseca Ana Catarina, Yesilot Nilufer, Roine Risto O, Waje-Andreassen Ulrike, von Sarnowski Bettina, Redfors Petra, Huhtakangas Juha, Numminen Heikki, Jäkälä Pekka, Putaala Jukka, SECRETO Study Group
Аннотация
MATERIALS AND METHODS: This prospective, multi-center, case-control study included 345 patients, aged 18-49 years, with first-ever, acute CIS. The control group included 345 age- and sex-matched stroke-free individuals. We measured height, weight, waist circumference, and hip circumference. Obesity metrics analyzed included body mass index (BMI), waist-to-hip ratio (WHR), waist-to-stature ratio (WSR), and a body shape index (ABSI). Models were adjusted for age, level of education, vascular risk factors, and migraine with aura.
RESULTS: After adjusting for demographics, vascular risk factors, and migraine with aura, the highest tertile of WHR was associated with CIS (OR for highest versus lowest WHR tertile 2.81, 95%CI 1.43-5.51; P=0.003). In sex-specific analyses, WHR tertiles were not associated with CIS. However, using WHO WHR cutoff values (>0.85 for women, >0.90 for men), abdominally obese women were at increased risk of CIS (OR 2.09, 95%CI 1.02-4.27; P=0.045). After adjusting for confounders, WC, BMI, WSR, or ABSI were not associated with CIS.
CONCLUSIONS: Abdominal obesity measured with WHR was an independent risk factor for CIS in young adults after rigorous adjustment for concomitant risk factors.