Advances in experimental medicine and biology · 2019
Initial Assessment of Lactate as Mediator of Exercise-Induced Retinal Protection.
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Sellers Jana T, Chrenek Micah A, Girardot Preston E, Nickerson John M, Pardue Machelle T, Boatright Jeffrey H
Аннотация
Physical exercise is protective in rodent models of retinal injury and disease. Data suggest that this is in part mediated by brain-derived neurotrophic factor (BDNF) signal transduction. It has been hypothesized that exercised-induced neuroprotection may be mediated by increases in circulating lactate that in turn alter BDNF secretion. We therefore tested whether mice undergoing a treadmill running regimen previously shown to be protective in a mouse model of retinal degeneration (RD) have increased serum levels of lactate. Lactate levels in exercised and non-exercised mice were statistically indistinguishable. A role for circulating lactate in exercise-induced retinal protection is unsupported.