A General Photocatalytic Decarboxylative Hydrogenation of Carboxylic Acids in Batch and Flow under Metal-Free Conditions.

We report a general acridine/thiol cooperative photocatalytic system for the metal- and base-free decarboxylative hydrogenation of carboxylic acids under mild conditions. This method accommodates a broad range of substrates with high chemoselectivity and excellent functional group tolerance. Moreover, the system operates efficiently in both batch and continuous flow modes, providing a practical and scalable protocol.