Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2001
Nicorandil can induce severe oral ulceration.
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Scully C, Azul A M, Crighton A, Felix D, Field A, Porter S R
Аннотация
OBJECTIVE: To increase physicians' and dentists' awareness that nicorandil is a potential inducer of severe mouth ulceration.
STUDY DESIGN: Nine new cases of ulceration from 3 European countries were included in this study.
RESULTS: Oral ulceration developed within 9 months of beginning nicorandil therapy, and ulcers resolved within 1 month of withdrawal of the drug. No lesions developed on other epithelia.
CONCLUSIONS: A number of drugs used in the care of patients with cardiovascular disease can cause oral adverse effects. Nicorandil, a new potassium-channel activator used in some countries to treat angina pectoris, precipitates persistent ulcerative stomatitis in some patients.
STUDY DESIGN: Nine new cases of ulceration from 3 European countries were included in this study.
RESULTS: Oral ulceration developed within 9 months of beginning nicorandil therapy, and ulcers resolved within 1 month of withdrawal of the drug. No lesions developed on other epithelia.
CONCLUSIONS: A number of drugs used in the care of patients with cardiovascular disease can cause oral adverse effects. Nicorandil, a new potassium-channel activator used in some countries to treat angina pectoris, precipitates persistent ulcerative stomatitis in some patients.