Медицинская библиотека · Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2001

Nicorandil can induce severe oral ulceration.

Scully C, Azul A M, Crighton A, Felix D, Field A, Porter S R

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Аннотация

OBJECTIVE

To increase physicians' and dentists' awareness that nicorandil is a potential inducer of severe mouth ulceration.

STUDY

DESIGN

Nine new cases of ulceration from 3 European countries were included in this study.

RESULTS

Oral ulceration developed within 9 months of beginning nicorandil therapy, and ulcers resolved within 1 month of withdrawal of the drug. No lesions developed on other epithelia.

CONCLUSIONS

A number of drugs used in the care of patients with cardiovascular disease can cause oral adverse effects. Nicorandil, a new potassium-channel activator used in some countries to treat angina pectoris, precipitates persistent ulcerative stomatitis in some patients.

Для цитирования: Scully C, Azul A M, Crighton A, Felix D, Field A, Porter S R. Nicorandil can induce severe oral ulceration.. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2001. DOI: 10.1067/moe.2001.110306.

Предметные рубрики MeSH

Adult Adverse Drug Reaction Reporting Systems Aged Aged, 80 and over Angina Pectoris Anti-Arrhythmia Agents Europe Female Humans Male Middle Aged Mouth Mucosa Nicorandil Oral Ulcer Potassium Channels Time Factors Tongue Diseases Vasodilator Agents

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