Future oncology (London, England) · 2021
Analysis of risk factors for immune-related adverse events in various solid tumors using real-world data.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Shimozaki Keitaro, Sukawa Yasutaka, Sato Yasunori, Horie Sara, Chida Akihiko, Tsugaru Kai, Togasaki Kazuhiro, Kawasaki Kenta, Hirata Kenro, Hayashi Hideyuki, Hamamoto Yasuo, Kanai Takanori
Аннотация
The aim of this study was to determine the risk factors for immune-related adverse events (irAEs) induced by immune checkpoint inhibitors. The authors conducted a retrospective study in which patients with malignant melanoma, non-small-cell lung cancer, gastric cancer or renal cell carcinoma who received anti-PD-1/PD-L1 antibodies were included. Of 247 patients, 118 developed a total of 182 irAEs. In the multivariate Fine-Gray regression analysis, serum albumin level ≥3.6 g/dl (hazard ratio: 1.62; 95% CI: 1.10-2.39; p = 0.015) and history of Type I hypersensitivity reactions (hazard ratio: 1.48; 95% CI: 1.02-2.14; p = 0.037) were significantly associated with the development of irAEs. High serum albumin levels and history of Type I hypersensitivity reactions are risk factors for irAEs.