Nederlands tijdschrift voor geneeskunde · 1994
[Satisfactory 5-year survival in 29 patients following surgery of a small metastasized tongue carcinoma (T1N0M0)].
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van der Meer P H, Snow G B, van der Waal I
Аннотация
OBJECTIVE: To determine the five-year survival rate of patients with a small (< 2 cm) squamous cell carcinoma of the anterior two-thirds of the tongue that had not shown evident cervical lymph node metastases at presentation.
DESIGN: Follow-up investigation.
SETTING: Free University Hospital, Amsterdam.
METHOD: In the period January 1st, 1970 to December 31, 1986, 36 patients were registered with a T1N0M0 squamous cell carcinoma of the anterior two-thirds of the tongue. Seven patients were excluded from follow-up study for various reasons (multiple carcinoma (4), histological diagnosis doubtful (2), lost to follow-up (1)). All remaining 29 patients were primarily treated by surgical excision with a margin of healthy tissue of approximately 1 cm.
RESULTS: In five patients (17%) a local recurrence was observed, in 7 (24%) one or more cervical lymph node metastases developed. Four patients withdrew from follow-up, three died from their tongue cancer, all within two years. Of the 22 patients who did not withdraw from follow-up and who did not die from other causes 19 (86%) were alive and well after five years.
CONCLUSION: Patients with a small squamous cell carcinoma of the anterior two-thirds of the tongue in whom initially no cervical lymph node metastases were palpable and who have primarily been treated by surgery, stand a good chance of cure, in spite of the development of regional lymph node metastases in almost 25% of them.
DESIGN: Follow-up investigation.
SETTING: Free University Hospital, Amsterdam.
METHOD: In the period January 1st, 1970 to December 31, 1986, 36 patients were registered with a T1N0M0 squamous cell carcinoma of the anterior two-thirds of the tongue. Seven patients were excluded from follow-up study for various reasons (multiple carcinoma (4), histological diagnosis doubtful (2), lost to follow-up (1)). All remaining 29 patients were primarily treated by surgical excision with a margin of healthy tissue of approximately 1 cm.
RESULTS: In five patients (17%) a local recurrence was observed, in 7 (24%) one or more cervical lymph node metastases developed. Four patients withdrew from follow-up, three died from their tongue cancer, all within two years. Of the 22 patients who did not withdraw from follow-up and who did not die from other causes 19 (86%) were alive and well after five years.
CONCLUSION: Patients with a small squamous cell carcinoma of the anterior two-thirds of the tongue in whom initially no cervical lymph node metastases were palpable and who have primarily been treated by surgery, stand a good chance of cure, in spite of the development of regional lymph node metastases in almost 25% of them.