Orvosi hetilap · 2016
[Renin and aldosterone determinations in hypertensive patients].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Hussein Tamás, Mezősi Emese, Bódis Beáta, Nemes Orsolya, Rucz Károly, Bajnok László
Аннотация
INTRODUCTION: The diagnostic algorithm of primary aldosteronism is burdened with uncertainties and, recently, it has been suggested that the sensitivity of the aldosterone/renin ratio used as a screening test - based on the suppression aldosterone - is low.
AIM: The primary aim was to test the accuracy of aldosterone/renin ratio.
METHOD: In a retrospective analysis of 309 hypertensive patients supine and ambulatory aldosterone levels were independently examined.
RESULTS: Aldosterone/renin ratio was elevated in 99 patients of whom 31 exhibited elevated supine aldosterone, as well. In 34 cases supine aldosterone was increased without elevation of the aldosterone/renin ratio. However, only 3 of them had concomitant low renin levels indicating that primary aldosteronism could not be ruled out. Abnormally increased renin was found in 69 patients, but only 59% of them had increased aldosterone level.
CONCLUSION: Sensitivity of aldosterone/renin ratio is high (91%) if used only in justified cases.
AIM: The primary aim was to test the accuracy of aldosterone/renin ratio.
METHOD: In a retrospective analysis of 309 hypertensive patients supine and ambulatory aldosterone levels were independently examined.
RESULTS: Aldosterone/renin ratio was elevated in 99 patients of whom 31 exhibited elevated supine aldosterone, as well. In 34 cases supine aldosterone was increased without elevation of the aldosterone/renin ratio. However, only 3 of them had concomitant low renin levels indicating that primary aldosteronism could not be ruled out. Abnormally increased renin was found in 69 patients, but only 59% of them had increased aldosterone level.
CONCLUSION: Sensitivity of aldosterone/renin ratio is high (91%) if used only in justified cases.