Neuroscience letters · 2012
Brain-derived neurotrophic factor Val66Met polymorphism is not associated with primary dystonia in a Chinese population.
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Ma Lingyan, Chen Yi, Wang Lin, Yang Yingmai, Cheng Fubo, Tian Yuan, Wan Xinhua
Аннотация
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a modulator of synaptic and neural plasticity. Considering the association between dystonia and abnormal sensorimotor cortex plasticity, BDNF may be a candidate gene that confers susceptibility to dystonia. However, the association between Val66Met polymorphism of BDNF gene and primary dystonia is controversial.
METHODS: A case-control study was performed to evaluate the association between Val66Met polymorphism in the BDNF gene and primary dystonia in a cohort of 252 Chinese patients and in 214 age- and gender-matched healthy control subjects.
RESULTS: No association was identified between Val66Met polymorphism and primary dystonia or cervical dystonia (P=0.309 and P=0.803 respectively). In a subsequent subgroup analysis, there was also no difference in the distribution for age of onset.
CONCLUSION: Our findings do not support that BDNF Val66Met polymorphism contributes to the risk of primary dystonia.
METHODS: A case-control study was performed to evaluate the association between Val66Met polymorphism in the BDNF gene and primary dystonia in a cohort of 252 Chinese patients and in 214 age- and gender-matched healthy control subjects.
RESULTS: No association was identified between Val66Met polymorphism and primary dystonia or cervical dystonia (P=0.309 and P=0.803 respectively). In a subsequent subgroup analysis, there was also no difference in the distribution for age of onset.
CONCLUSION: Our findings do not support that BDNF Val66Met polymorphism contributes to the risk of primary dystonia.