Archives of endocrinology and metabolism · 2021
Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Garmes Heraldo Mendes, Boguszewski César Luiz, Miranda Paulo Augusto Carvalho, Martins Manoel Ricardo Alves, da Silva Silvia Regina Correa, Abucham Julio Zaki, de Castro Musolino Nina Rosa, Vilar Lucio, Portari Luiz Henrique Corrêa, Gadelha Mônica Roberto, Kasuki Leandro, Naves Luciana Ansaneli, Czepielewski Mauro Antônio, de Almeida Tobias Skrebsky, Duarte Felipe Henning Gaia, Glezer Andrea, Bronstein Marcello Delano
Аннотация
Hypopituitarism is a disorder characterized by insufficient secretion of one or more pituitary hormones. New etiologies of hypopituitarism have been recently described, including head trauma, cerebral hemorrhage, and drug-induced hypophysitis. The investigation of patients with these new disorders, in addition to advances in diagnosis and treatment of hypopituitarism, has increased the prevalence of this condition. Pituitary hormone deficiencies can induce significant clinical changes with consequent increased morbidity and mortality rates, while hormone replacement based on current guidelines protects these patients. In this review, we will first discuss the different etiologies of hypopituitarism and then address one by one the clinical aspects, diagnostic evaluation, and therapeutic options for deficiencies of TSH, ACTH, gonadotropin, and GH. Finally, we will detail the hormonal interactions that occur during replacement of pituitary hormones.