Veterinary anaesthesia and analgesia · 2024
A comparative study of detomidine delivery via intranasal or intramuscular routes in calves undergoing disbudding.
Сравнительное исследованиеСтатьяRandomized Controlled Trial, VeterinaryНазвание и аннотация: Перевод пока не подготовлен
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Cinar Harun, Yanmaz Latif Emrah, Cetin Mehmet Nur, Polat Dogukan, Ozbeyli Aybike
Аннотация
OBJECTIVE: To compare the sedative and physiological effects of intranasal (IN) and intramuscular (IM) delivery of detomidine in calves.
STUDY DESIGN: Prospective, randomized experimental study.
ANIMALS: A total of 20 healthy calves, aged 15.6 ± 4.2 days old, with body masses ranging from 40 to 60 kg.
METHODS: Calves were randomly assigned to be administered detomidine (0.03 mg kg-1) by either IN or IM route. The onset of sedation, duration of sedation and sedation score (SS) were recorded. Heart rate (HR), peripheral arterial hemoglobin oxygen saturation (SpO2), noninvasive systolic and diastolic arterial pressures (SAP and DAP, respectively), respiratory rate (fR) and rectal temperature (RT) were measured immediately before drug delivery (baseline), at 10 (T10), 15 (T15), 20 (T20) and 30 (T30) minutes after drug delivery. Calves underwent disbudding at T25. Comparisons between groups for physiological variables were performed with an independent t-test. Duration of sedation and SS were assessed with a Mann-Whitney test.
RESULTS: Onset of sedation was 6.8 ± 2.3 (mean ± standard deviation) and 14.1 ± 6.6 minutes in groups IM and IN, respectively (p = 0.005). Duration of sedation was 32.5 (26-65) [median (range)] and 33 (26-52) minutes in groups IM and IN, respectively (p = 0.622). SS was significantly higher in the IM group than the IN group at T15 (p = 0.015) and T20 (p = 0.039). HR was significantly higher with IN than with IM at T20 (p = 0.022). RT was significantly lower in IN than in IM at T30 (p = 0.020). fR, SpO2, SAP and DAP did not differ significantly between groups.
CONCLUSIONS AND CLINICAL RELEVANCE: The IN delivery of detomidine resulted in a slower onset of sedation compared with IM injection, although the duration of sedation did not differ between the two treatments.
STUDY DESIGN: Prospective, randomized experimental study.
ANIMALS: A total of 20 healthy calves, aged 15.6 ± 4.2 days old, with body masses ranging from 40 to 60 kg.
METHODS: Calves were randomly assigned to be administered detomidine (0.03 mg kg-1) by either IN or IM route. The onset of sedation, duration of sedation and sedation score (SS) were recorded. Heart rate (HR), peripheral arterial hemoglobin oxygen saturation (SpO2), noninvasive systolic and diastolic arterial pressures (SAP and DAP, respectively), respiratory rate (fR) and rectal temperature (RT) were measured immediately before drug delivery (baseline), at 10 (T10), 15 (T15), 20 (T20) and 30 (T30) minutes after drug delivery. Calves underwent disbudding at T25. Comparisons between groups for physiological variables were performed with an independent t-test. Duration of sedation and SS were assessed with a Mann-Whitney test.
RESULTS: Onset of sedation was 6.8 ± 2.3 (mean ± standard deviation) and 14.1 ± 6.6 minutes in groups IM and IN, respectively (p = 0.005). Duration of sedation was 32.5 (26-65) [median (range)] and 33 (26-52) minutes in groups IM and IN, respectively (p = 0.622). SS was significantly higher in the IM group than the IN group at T15 (p = 0.015) and T20 (p = 0.039). HR was significantly higher with IN than with IM at T20 (p = 0.022). RT was significantly lower in IN than in IM at T30 (p = 0.020). fR, SpO2, SAP and DAP did not differ significantly between groups.
CONCLUSIONS AND CLINICAL RELEVANCE: The IN delivery of detomidine resulted in a slower onset of sedation compared with IM injection, although the duration of sedation did not differ between the two treatments.