Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica · 2025
Gastrointestinal stromal tumor surgery in pediatrics.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Israel S D, Del Cañizo A, Monje S, Sáenz M, Bueno J, Ordóñez J, Pérez Egido L, García Casillas M A, Cerdá J A, Bada Bosch I, Fanjul M, Peláez D, de Agustín J C
Аннотация
INTRODUCTION: Gastrointestinal stromal tumors (GIST) are infrequent in pediatric patients. The management of metastatic and irresectable tumors is usually non-surgical, with tyrosine-kinase inhibitors being the treatment of choice.
CLINICAL CASE: We present the case of a 14-year-old female patient with a metastatic and irresectable GIST treated with sunitinib that required surgery as a result of severe hemoperitoneum episodes with anemia and hemodynamic instability. A cytoreductive surgery with R2 resection margins was carried out. After a 10-year follow-up period, the patient remains under oncological treatment.
DISCUSSION: The treatment of metastatic and irresectable GIST consists of tyrosine-kinase inhibitors. Evidence regarding the role of surgery remains limited, which means extreme caution should be exerted when indicating surgical treatment. However, surgery is still a useful tool within the array of therapeutic options.
CLINICAL CASE: We present the case of a 14-year-old female patient with a metastatic and irresectable GIST treated with sunitinib that required surgery as a result of severe hemoperitoneum episodes with anemia and hemodynamic instability. A cytoreductive surgery with R2 resection margins was carried out. After a 10-year follow-up period, the patient remains under oncological treatment.
DISCUSSION: The treatment of metastatic and irresectable GIST consists of tyrosine-kinase inhibitors. Evidence regarding the role of surgery remains limited, which means extreme caution should be exerted when indicating surgical treatment. However, surgery is still a useful tool within the array of therapeutic options.