Laboratory medicine · 2020
Low S-adenosylmethionine/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease.
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Kruglova Maria Petrovna, Grachev Sergej Vital'evich, Bulgakova Polina Olegovna, Ivanov Alexander Vladimirovich, Virus Edward Danielevich, Nikiforova Ksenya Alexandrovna, Fedoseev Anatolij Nikolaevich, Savina Galina Dmitrievna, Kubatiev Aslan Amirkhanovich
Аннотация
OBJECTIVE: To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD).
METHODS: Case-control study including 50 patients with CKD and 20 healthy volunteers.
RESULTS: SAM level and SAM/SAH ratio in urine were significantly lower in patients than in control individuals (P <.001 and P = .01, respectively). The estimated glomerular filtration rate was associated with the SAM level (P = .04) and the SAM/SAH ratio in urine (P = .01).
CONCLUSION: CKD is associated not only with the decline in the SAM level but also with the decrease in the SAM/SAH ratio in urine. Thus, use of the urinary SAM/SAH ratio as a noninvasive diagnostic indicator of renal function seems promising.
METHODS: Case-control study including 50 patients with CKD and 20 healthy volunteers.
RESULTS: SAM level and SAM/SAH ratio in urine were significantly lower in patients than in control individuals (P <.001 and P = .01, respectively). The estimated glomerular filtration rate was associated with the SAM level (P = .04) and the SAM/SAH ratio in urine (P = .01).
CONCLUSION: CKD is associated not only with the decline in the SAM level but also with the decrease in the SAM/SAH ratio in urine. Thus, use of the urinary SAM/SAH ratio as a noninvasive diagnostic indicator of renal function seems promising.