Korea Seroprevalence Study of Monitoring of SARS-COV-2 Antibody Retention and Transmission (K-SEROSMART): findings from national representative sample.
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Han Jina, Baek Hye Jin, Noh Eunbi, Yoon Kyuhyun, Kim Jung Ae, Ryu Sukhyun, Lee Kay O, Park No Yai, Jung Eunok, Kim Sangil, Lee Hyukmin, Hwang Yoo-Sung, Jung Jaehun, Lee Hun Jae, Cho Sung-Il, Oh Sangcheol, Kim Migyeong, Oh Chang-Mo, Yu Byengchul, Hong Young-Seoub, Kim Keonyeop, Jung Sun Jae, Han Mi Ah, Lee Moo-Sik, Lee Jung-Jeung, Hwangbo Young, Yim Hyeon Woo, Kim Yu-Mi, Lee Joongyub, Lee Weon-Young, Park Jae-Hyun, Oh Sungsoo, Jo Heui Sug, Kim Hyeongsu, Kang Gilwon, Nam Hae-Sung, Lee Ju-Hyung, Oh Gyung-Jae, Shin Min-Ho, Ryu Soyeon, Hwang Tae-Yoon, Park Soon-Woo, Kim Sang Kyu, Seol Roma, Park Ki-Soo, Kim Su Young, Kwon Jun-Wook, Kim Sung Soon, Kim Byoungguk, Lee June-Woo, Jang Eun Young, Kim Ah-Ra, Nam Jeonghyun, Korea Community Health Survey Group, Lee Soon Young, Kim Dong-Hyun
Аннотация
METHODS: In August 2022, a survey was conducted among 10,000 household members aged 5 years and older, in households selected through two stage probability random sampling. During face-to-face household interviews, participants self-reported their health status, COVID-19 diagnosis and vaccination history, and general characteristics. Subsequently, participants visited a community health center or medical clinic for blood sampling. Blood samples were analyzed for the presence of antibodies to spike proteins (anti-S) and antibodies to nucleocapsid proteins (anti-N) SARS-CoV-2 proteins using an electrochemiluminescence immunoassay. To estimate the population prevalence, the PROC SURVEYMEANS statistical procedure was employed, with weighting to reflect demographic data from July 2022.
RESULTS: In total, 9,945 individuals from 5,041 households were surveyed across 258 communities, representing all basic local governments in Korea. The overall population-adjusted prevalence rates of anti-S and anti-N were 97.6% and 57.1%, respectively. Since the Korea Disease Control and Prevention Agency has reported a cumulative incidence of confirmed cases of 37.8% through July 31, 2022, the proportion of unreported infections among all COVID-19 infection was suggested to be 33.9%.
CONCLUSIONS: The K-SEROSMART represents the first nationwide, community-based seroepidemiologic survey of COVID-19, confirming that most individuals possess antibodies to SARS-CoV-2 and that a significant number of unreported cases existed. Furthermore, this study lays the foundation for a surveillance system to continuously monitor transmission at the community level and the response to COVID-19.